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The Cell Danger Response (CDR) is an ancient metabolic response to threat, according to Dr. Naviaux who published his 2014 paper “Metabolic features of the cell danger response”. The cell danger response occurs when cells are damaged by “chemical, physical, or biological threats”. Cell danger response focuses on conserving resources to protect the cell from harm.
In the short term, the CDR serves to protect but long term. Once the “threat” is nullified, the CDR turns off and the cells take steps to reverse the effects of the CDR resulting in healing. Chronic CDR has the ability to disrupt the function of every cell in the body. This will have a direct impact on the gut and microbiome, mitochondrial function, neurotransmission and detoxification capacity.