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This has been linked to issues that impact people with neuroimmune disease and environmental illness, like poor methylation and low glutathione status and chronic traumatic encephalopathy (brain injury or disease). It can result in low energy, pain and many unpleasant mental, emotional and behavioural symptoms.
The majority of the brain is made up of immune cells (glia). Glia make up 85% of fat that makes up the brain. The glia are play a role in every aspect of brain function and health. Glia “transmit” or “broadcast” brain chemicals (neurotransmitters) throughout the brain playing a role in every aspect of brain function. To do this a lot of energy is required, as well as a proper balance of other brain chemicals like glutamate.
Glutamate is the most abundant neurotransmitter in the brain. It is essential for the development and function of the brain. In high amounts, it can change the way to brain functions and even cause damage. Glutamate increases when glia (the immune cells in the brain) encounter chemicals, metals or microbes. The glia work to control the threat and repair damage to the brain. If Glutathione and GABA is low, glutamate is poor regulated and harmful.
The brain requires adequate levels of glutathione to manage glutamate. Glutathione is the master antioxidant in the body and brain. It helps to protect cells from damage and is needed to “mop” up excess glutamate.